The crash happened en route around 10 a.m. and involved two T-38C Talon trainer planes, officials said in a Facebook post.
One of the surviving pilots was taken to Val Verde Regional Medical Center, where they were treated and released. The second pilot is in critical condition and has been evacuated by air to Brooke Army Medical Center, according to the post.
“Our hearts, thoughts and prayers go out to our pilots involved in this incident and their families,” said 47th Training Wing Commander, Colonel Craig Prather.
The people involved have yet to be identified.
The base is located near Del Rio and is used as a training site for the United States Air Force, Air Force Reserves, National Guard and allied air forces.