Adverse Events of the COVID-19 Vaccine and the Placebo Effect

The placebo effect is the well-known phenomenon in which a person’s physical or mental health improves following treatment with no pharmacological therapeutic benefit (e.g. a sugar pill or a full syringe). Salty water). Additionally, a patient’s negative outcome regarding treatment is known as the nocebo effect.

The exact biological, psychological, and genetic basis of the placebo effect is unclear. However, some argue that unconscious factors tied to the patient-doctor relationship automatically reduce the volume of symptoms.

The team analyzed data from 12 clinical trials of a COVID-19 vaccine that included side effects reports from 22,578 placebo recipients and 22,802 vaccine recipients.

It is seen that More than 35% of placebo users (after the first injection) and 32% after the second dose experienced systemic adverse events such as fever, headache, and fatigue.

“Adverse events following placebo treatment are common in randomized controlled trials. It is important to collect systematic evidence regarding these nocebo reactions in vaccine trials. importance to COVID-19 vaccination worldwide, especially because concerns about reported adverse events are the reason for the vaccine’s use.” Julia W. Haas, lead author, an investigator in the Placebo Research Program at BIDMC, said.

Source: Medindia


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