Amazing long-term results with newborn kidney transplants

Care providers often wait until the infant is older because of the technical challenges of performing this surgery on a young child. Most prefer to put newborns on dialysis in the hope of improving patient survival rates and limiting transplant failure, which is when the body rejects a transplanted organ.

To compare the success of infant and adolescent kidney transplants, a new study looked at 2,696 pediatric kidney transplant patients who received their first kidney transplant between January 1, 2000 and day 31. December 2015.

Of these patients, 27 were infants. The study excluded transplant recipients who failed on the day of their transplant.

The study measured after-school outcomes for three age groups of children, based on their age at the time of transplantation: infants (1 year of age or younger), infants (ages 1 to 11 years of age) and adolescents. (from 12 to 17 years old).

The study found that the number of newborn kidney transplants remained stable, going from zero over many years to a peak of five in 2006. There was no trend in the number of newborn kidney transplants over time.

Newborn recipients are more likely to be male, have a structural cause of chronic kidney failure, and have hypoalbuminemia, a low level of the protein albumin in the blood.

The majority of infant and pediatric kidney recipients underwent a period of dialysis prior to transplantation. Highest graft failure rate seen in the first year after transplantation: 10.4% in infants compared with 3.8% in both infants and adolescents.

But this failure rate decreases over time. Five years after transplantation, 16.4% of infants, 13.6% of infants and 19.9% ​​of adolescents experienced transplant failure.

The study highlights that all kidney transplants should be performed in centers with experience, like UC Davis Children’s Hospital, to reduce risks.

Research that captures data from the OPTN database reveals that kidney transplants are concentrated in a few geographical areas, reflecting the comfort and expertise of some transplant teams to perform kidney transplants for patients. Infant.

This study is an optimistic reminder that transplant centers with the technical expertise and experience to care for this high-risk population should not delay transplant performance based solely on size and age. receiver’s work.

Source: Medindia


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