Health

Antibiotics linked to inflammatory bowel disease


Using a Danish national database, which includes nearly all of the people’s medical records, the researchers looked at prescription records for people 60 years of age and older who were newly diagnosed with the disease. inflammatory bowel disease between 2000 and 2018. The study looked at the number of antibiotics prescribed, how they were recently prescribed in relation to diagnosis, and the specific antibiotics used.

Research shows that any antibiotic use is associated with a higher incidence of inflammatory bowel disease and a significantly increased risk with each course of treatment. After a prescription, patients were 27% more likely to be diagnosed with inflammatory bowel disease than those who did not take antibiotics.

Antibiotics for digestive disorders

With two courses, the risk increased by 55 percent, and with three courses, it increased by 67 percent. With four courses, the risk increases by 96%; and for five or more, seniors were 2.3 times more likely, or 236 percent, more likely to receive a new inflammatory bowel disease diagnosis than those who had not taken antibiotics in the previous five years .

New diagnoses were highest when antibiotics were prescribed one to two years earlier, but the risk remained increased for prescriptions two to five years before diagnosis. An association was found for all antibiotics, with the exception of nitrofurantoin, commonly prescribed for urinary tract infections.

Antibiotics commonly prescribed for gastrointestinal infections are more likely to be associated with a new inflammatory bowel disease diagnosis. The researchers skipped prescriptions less than a year before diagnosis to reduce the likelihood that the prescriptions were for symptoms of an undiagnosed gastrointestinal illness.

The study has implications for diagnosing older adults with new gastrointestinal symptoms. Inflammatory bowel disease, Dr. Faye says, can be easy to overlook at this age, especially when there is a history of antibiotic prescriptions.

Research also has ramifications for antibiotic administration. In addition to preventing the development of multidrug-resistant organisms, the rational use of antibiotics is important to prevent inflammatory bowel disease.

“Antibiotic management is important; but avoiding antibiotics at all costs is not the right answer,” says Dr. Faye. “If you’re not sure what you’re being treated for, I would be cautious. If a patient comes in with an obvious infection and they need antibiotics, they shouldn’t be turned down because of these findings.” The study was carried out in partnership with the PREDICT Program of the Danish National Center of Excellence. The authors did not report any conflicts of interest in connection with this study.

Source: Eurekalert



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