Health

Biological pacemakers can reset the heart’s natural rhythms


Manaaki Manawa led the study and the results were published in a leading journal

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“If you analyze the frequencies of your heart rate, you’ll see that your heart rate goes hand in hand with your breathing. It goes up on inspiration and goes down on expiration, and that’s a natural phenomenon at all. animals and humans. And we’re talking about very ancient animals that were present on the planet 430 million years ago.”

All patients with cardiovascular disease lose heart rate variability, which is an early sign that something is wrong. “People with high blood pressure, people with heart failure, whose heart rate is not regulated by breathing.

It can be a little bit, but it’s very, very depressing, very inhibiting,” said Paton. We decided that we would put heart rate variability back in animals with heart failure and see if it would do any good. “

Following the positive signals in mice, the latest study to be published was in a large animal model of heart failure, led by Dr Julia Shanks and Dr Rohit Ramchandra.

Dr Ramchandra said: “And the important news is that we believe we have found a way to reverse heart failure.

Dr. Julia Shanks, who conducted the study, explains, “There’s really nothing on the market that can cure heart failure. All drugs will make you feel better.

They don’t solve the problem that you have damaged tissue that doesn’t contract as effectively as it did in the beginning. Our new pacemaker delivers this change, naturally, in what you might call ‘nature’s pacemaker.’

“For now, pacemakers trigger a steady beat in terms of accuracy, but this study shows that introducing a natural variation in heart rate improves the heart’s ability to pump blood,” said Dr. Ramchandra. The other big news is that we got a 20% improvement in cardiac output, which is the heart’s ability to efficiently pump blood around the body. And 20% is a big number.”

“The pacemaker is almost like a biological device,” says Paton. “It understands signals from the body that tell the device when we’re breathing in and when we’re exhaling. And then the device has to communicate with the body again and regulate the heart rate during inhalation and descent. while exhaling . . . “

Upon seeing the results, interventional cardiologist Dr. Wil Harrison from Middlemore Hospital in Auckland commented: “The study is exciting. We found clinically that the permanent pacing was ‘abiotic’ ‘ to a certain extent, and pacing cardiomyopathy is a well-recognized phenomenon. It will be interesting to see if the findings are translated into humans.”

Dr Martin Stiles, a cardiologist from Waikato Hospital, in Hamilton, New Zealand, who will lead the trial, said: “We often see improvements in heart function with current pacemakers. but this circadian pacemaker has far exceeded our expectations. This discovery could revolutionize the pacing of heart failure patients in the future.”

The following steps are well underway, with plans to recruit patients into a trial planned later this year in New Zealand. Ceryx Medical, a startup that owns an IP on the unique electronics in biological pacemakers, will support the trial. The study was funded by the Medical Research Council of New Zealand.

Source: Medindia



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