The study included 1363 patients who were quantitatively evaluated for D-dimer within 24 hours of suspected or confirmed snakebite.
Diagnostic performance of the D-Dimer . Test
D-dimer values increased to 2.5 mg/L within three hours of the bite among 95% of patients who developed VICC and to less than 2.5 mg/L for 95% of patients not examined within six hours after being bitten by a snake.
Diagnostic performance improved in the first three hours after a snake bite; for quantitative D-dimer testing at 2-6 hours.
In one of the 84 patients who developed VICC-associated acute kidney injury, D-dimer values exceeded 4 mg/L within 24 hours of the bite.
The study concluded that the estimated D-dimer concentration 2-6 hours after a snake bite, with a cut-off value of 2.5 mg/L, could serve as an important diagnostic tool for detecting VICC.