Health

Can obesity increase the risk of female reproductive disorders?


Female reproductive disorders are common conditions that affect the health and well-being of many people. However, the role of obesity in the development of female reproductive conditions has not been studied.

To investigate the causal link between obesity, metabolic hormones, and female reproductive disorders, researchers conducted a Mendelian randomized study with 257,193 European women aged 40-69 years. They accessed records from the UK Biobank, a large-scale biomedical database containing the medical, environmental and genetic information of the participants.

The researchers then created a statistical model to estimate the association of body mass index and waist-to-hip ratio with the risk of many female reproductive diseases including endometriosis. endometriosis, heavy menstrual bleeding, preeclampsia, and infertility.

Researchers have found an observed link between obesity and a range of female reproductive disorders, including uterine fibroids, polycystic ovary syndrome, heavy menstrual bleeding, and preeclampsia.

They also found that some genetic variations associated with obesity were also associated with female reproductive disorders, but the strength of those associations varied according to obesity type and reproductive status.

The study had some limitations, such as the low prevalence of female reproductive disorders among the participants and the lack of data on body mass index and waist-to-hip ratio prior to disease onset.

According to the authors, “We provide genetic evidence that both generalized and central obesity play a etiological role in a wide range of female reproductive conditions, but the magnitude of the association This relationship is fundamentally different between conditions.Our results suggest that there is a need to explore the mechanisms that mediate the causal link of overweight and obesity on gynecological health in order to define prevention goals. disease and treatment”.

Source: Eurekalert



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