is the main component of this mechanism. This study successfully detected protein misalignment in living cells using fluorescence technique.
A little stress can be good for you – commonly spoken lines are now reinforced by current research as they uncover a new mechanism that reverses the formation of aggregates, not by eliminating them, but by ‘reconstructing’ they.
Effects of stress on dementia
“Just like when we are stressed by a heavy workload, so cells can become ‘stressed’ if they are required to produce large amounts of protein. There are many reasons why this is. can occur, such as when they produce antibodies in response to an infection.We focused on highlighting a component of the cell called the endoplasmic reticulum (ER), which is responsible. produce about a third of our protein – and it is assumed that this stress can cause misalignment,” said Dr. Edward from Cambridge University.
Therefore, the research team hypothesized that Emphasizing ER can lead to misfolding of proteins and aggregates by reducing its ability to function correctly, leading to increased synthesis. However, to their surprise, the opposite was found to be true.
“We were surprised to find that cellular stress actually removes the aggregates – not by degrading them or clearing them out, but by unraveling the aggregates, potentially allowing if we can figure out how to wake up this mechanism without stressing it, Dr. Avezov said, cells – which can do more damage than good – when That’s where we can figure out how to treat some dementias.
Source: Medindia
