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According to a study at Kumamoto University, angiogenesis was identified as having a unique “switch”.

The research team systematically analyzed epigenetic changes in angiogenesis-stimulated vascular endothelial cells (blood vessels) to challenge conventional wisdom.

‘Unique epigenetic changes responsible for the stimulation of angiogenesis (angiogenesis)-specific genes were discovered by the scientists. ‘

It has been found that a unique epigenetic modification (bidirectional switch of epigenetic marks – specific for key transcription factors) causes genes required for angiogenesis and revealed that the histone regulators responsible for this modification are critical for postnatal angiogenesis.

The findings may have potential for compiling epigenetic databases for normal endothelial cells and for selective epigenetic drug discovery for protection against age-related vascular diseases.

Source: Medindia



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