Cardiovascular risk factors associated with increased risk of dementia

The study looked at 1,244 people with an average age of 55 who were considered healthy in terms of heart health and memory skills at the start of the study. Participants were given memory tests, health checks, and completed a lifestyle questionnaire every five years for up to 25 years.

Of all the participants, 78, or 6%, developed dementia due to Alzheimer’s disease during the study, and 39, or 3%, developed vascular dementia.

Cardiovascular disease risk was determined using the Framingham Risk Score predicting 10-year risk of cardiovascular events. It looks at factors including a person’s age, sex, body mass index (BMI), blood pressure, and whether they smoke or have diabetes. Participants started the study with an average 10-year risk ranging from 17% to 23%.

The researchers determined who was at increased risk of cardiovascular disease by comparing the participants with average progression of cardiovascular disease risk.

Those in the study with stable cardiovascular disease risk had an average 20 percent 10-year risk of cardiovascular events over the course of the study, while those with an average increased risk increased from 17 percent to 17 percent. 38% throughout the study, and those at risk of speeding increased from 23% to 62% at the end of the study.

The researchers determined that when compared with people with stable cardiovascular disease risk, those with accelerated cardiovascular disease risk were three times more likely to develop dementia-related Alzheimer’s disease. up to 6 times and 3 to 4 times higher risk of vascular dementia. They were also 1.4 times more likely to experience memory loss in middle age.

“Several risk factors have been increased in people at increased risk of acceleration, suggesting that such acceleration may come from the accumulation of damage from a combination of risk factors,” said Farnsworth von Cederwald. muscle over time. “Therefore, it is important to identify and address all risk factors in each person, such as lowering high blood pressure, stopping smoking, and reducing BMI, rather than just addressing risk factors.” individual risk in an attempt to prevent or slow dementia.”

One limitation of the study was its inability to determine whether the decline leading to dementia was preceded by a rapidly increasing risk of cardiovascular disease. Farnsworth von Cederwald said it could not be ruled out that other factors could also contribute, so further research is needed.

The research was funded by the Swedish Brain Foundation, the Knut and Alice Wallenberg Foundation, and the Swedish Humanities and Social Sciences Foundation.

Learn more about dementia at, the home page of the American Academy of Neurology’s free patient and care journal that focuses on the intersection of neurological disease and brain health. Follow Brain & Life® on Facebook, Twitter and Instagram.

When posting on social media channels about this research, we encourage you to use the hashtags # #Neurology and #AANscience.

The American Academy of Neurology is the world’s largest association of neuroscientists and neuroscience professionals, with more than 38,000 members. AAN strives to promote the highest quality patient-centered neurological care. Neurologists are doctors with specialized training in the diagnosis, treatment, and management of disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.

Source: Eurekalert

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