Health

Clean Filters Can Virus Vectors Improve Human Health?


Virus vectors are the tools by which scientists deliver modified, harmless versions of viruses to human cells. As functional genetic material in vaccines, they perform the important function of instructing cells to recognize and fight disease, including viruses.

The rush to develop a coronavirus vaccine confirms this challenge. Manufacturers have struggled to produce membranes to filter out viral vectors and virus-like particles, mainly due to membrane capacity and fouling, which has caused production delays. vaccine export. The membrane’s strong performance under a wide range of operating conditions also results in production delays.

For this project, the Qian-led researchers will create a scalable downstream manufacturing platform to replace the standard processes of plastic-based centrifugation and chromatography, both of which are difficult. scale up in production.

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The project will require the production of materials from two common viral vectors for gene therapy, virus seeds for vaccine applications, and advanced microfiltration for bioreactor harvesting. The researchers will design, fabricate and characterize the high-capacity membranes and will develop a membrane chromatographic method for separating full and empty viral capsids.

The researchers will use state-of-the-art bioanalytical methods for detection and quantification, and will develop a readiness and acceptance study to help advance the technology towards commercial production.

Arkansas researchers – co-investigator Bob Beitle, professor of chemical engineering; Ranil Wickramasinghe, Distinguished Professor of Chemical Engineering; and several others, besides Qian – will collaborate with researchers at the University of Kentucky and Clemson University.

In addition to the significant human impact, the project will provide economic benefits to Arkansas, Kentucky, and South Carolina, where regional incubators for biotechnology development will be established.

Source: Eurekalert



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