COVID-19 Omicron Variation Blocks Evading Virus

a journal of the American Society for Microbiology.

“We discovered in a January 2021 study that in people previously infected with the parent strain of COVID, specific epithelium [portions of a protein that elicit an immune response] The word virus is recognized by cells of the immune system called CD8 T lymphocytes, said lead author Andrew Redd, Ph.D., assistant professor of medicine at the university. + or killer T cells and that this recognition enables a cell-mediated attack on COVID. Johns Hopkins University School of Medicine and staff scientist at NIAID.

Other research groups in the United States and South Africa demonstrated very similar results in people who were previously infected with or vaccinated against the original COVID-19 strain.

Immune cells are known for their ability to eliminate foreign invaders such as bacteria and viruses from the body.. The T cells used in the latest study were from blood samples collected in 2020 from 30 recovered patients from mild to moderate COVID-19 cases.

Convalescent plasma donors have six human leukocyte antigens (cell surface proteins that regulate the immune system and are part of each person’s genetic profile), representing more than 73% of the U.S. population. Ky.

During that evaluation, donor samples were sent to ImmunoScape for the daunting task of determining which T cells responded to SARS-CoV-2.

More specifically, the company’s deep immune cell profiling method revealed which viral proteins induce a T-cell-directed response – data that could provide valuable insight into the specifics of the virus. T cell function.

In the initial analysis, the researchers found that T cells from convalescent donors recognized 52 out of 408 epithelium.

In the latest study, the researchers examined 52 previously identified epithelium in convalescent blood samples to determine if they were altered by genetic changes that help the virus evade the virus’ ability to survive. cell mediated immunity.

They found a low prevalence epithelium from the omicron spike protein that had a small change from its precursor in the original virus.

Overall, The omicron variant is known to have more than 50 mutational differences between it and the original SARS-CoV-2 strain, but it seems that the virus has not developed the ability to avoid T-cell recognition..

Although significant cell-mediated immunity appears to have been maintained from the original SARS-CoV-2 through its subsequent variants, further study is still needed to fully determine the reasons. why people with these protective measures can still get sick from omicrons.

Source: Medindia

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