Genetic links found between severe COVID-19 and other disorders

Some people with COVID-19 get sicker than others. Previous research has identified certain variants in specific human genes that are associated with a more severe COVID-19 illness.

Some of these variations may also be associated with other medical conditions that may already be well understood; Identifying these shared variants could improve understanding of COVID-19 and shed light on potential new therapeutics.

To identify shared variants, Verma and colleagues used an unprecedented dataset of genotype information linked to the electronic health record (EHR) data of more than 650,000 veterans. USA.

The Phenomenonal Association Study (PheWAS) was conducted to examine the association between variants commonly found in Veterans who have experienced severe COVID-19 and variants associated with multiple selection. Medical conditions


The analysis shows that certain variants associated with COVID-19 are also associated with known risk factors for COVID-19.

Particularly strong links were found for variants associated with venous thromboembolism and thrombosis, as well as type 2 diabetes and ischemic heart disease – two risk factors for COVID-19 known.

The analysis also found a genetic link between severe COVID-19 and neutropenia for Hispanic and African Veterans; these links do not appear for links of European origin.

Among respiratory conditions, idiopathic pulmonary fibrosis and chronic alveolar lung disease share a genetic association with severe COVID-19, but other respiratory infections and chronic obstructive pulmonary disease (COPD) ) does not.

Certain variants associated with severe COVID-19 have also been associated with a reduced risk of autoimmune diseases, such as psoriasis and lupus. These findings highlight the need to carefully consider different aspects of the immune system when developing new treatments.

Despite some limitations of the PheWAS method, these findings could help deepen our understanding of COVID-19 and guide the development of new treatments.

Verma concludes, “The study demonstrates the value and impact of major biobanks linking genetic variants with EHR data in the current and future public health response to pandemics. The MVP is one of the most diverse cohorts in the United States.

We had a unique opportunity to scan thousands of conditions recorded before the COVID-19 pandemic. We have a better understanding of the genetic makeup of COVID-19 risk factors and complications of the disease. “

One thing that stands out to us is the high number of immune-mediated conditions that share genetic makeup with severe manifestations of COVID-19“Added co-author Katherine Liao.

The nature of the associations sheds light on how the SARS-CoV2 virus pushes up a pressure point in the human immune system and its ongoing balancing act to fight infection while maintaining sufficient keep it under control so it doesn’t become an autoimmune process that attacks itself.. “

Source: Medindia

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