Health

Here’s how belly fat increases your risk of metabolic disease


Using samples from 538 TwinsUK participants and combining genetic data, gene function, diet and health, the researchers examined epigenetic markers across the genome (full set). a person’s genetic material) and found nine genes that were highly associated with metabolic disease risk.

Among these is a gene whose epigenetic changes have been identified as a potential mechanism through which diet can influence abdominal fat accumulation, as well as other epigenetic markers. produce genetic risk effects on metabolic health.

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The findings also allow the researchers to characterize the molecular changes that occur as a result of an increase in belly fat and the impact of these changes on gene function and insulin resistance.

Dr Jordana Bell, Epigenomics Reader in School of Life said: “With obesity rates rapidly increasing worldwide, it is important that we understand how elevated body fat affects us. at the molecular level and how does this lead to metabolic disease risk.” & Population Science.

Metabolic diseases – the most common of which is diabetes – disrupts normal metabolism, or the process of converting food into energy at the cellular level.

While previous studies in this area have explored the role of epigenetic markers in overall obesity using body mass index (BMI), deep abdominal fat accumulation has been known to be a higher risk factor for metabolic disease than BMI.

Dr Bell added: “Our study brings us one step closer to this goal by identifying the epigenetic signature of excess belly fat, understanding the genetic triggers and the diet, and describe its functional effects and clinical consequences on insulin resistance”.

Based on the study results, the researchers also developed an epigenetic predictor of insulin resistance, linking their findings to the clinical consequences of increased abdominal fat.

“It’s been exciting to see that when we combine many different layers of biological information, we can begin to shed light,” said Colette Christiansen, a PhD researcher in the School of Life & Population Sciences. reveal the mechanisms that lead to our state of biological health.”

Source: Eurekalert



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