How Nitric Oxide Targets Triple Negative Breast Cancer?

Nitric oxide interacts with various components of the large network of proteins and other molecules that surround, support, and give structure to tumor cells and tissues in the body. Hyaluronic acid is one of the main components of this network and the material of choice for the fabrication of these hydrogels.

“HA plays many roles in tumor tissues,” says Amir. “However, its interactions with nitric oxide have not been well studied. The study, recently published in the journal Biomacromolecules, attempts to understand the mechanism of these interactions and the different effects on nitric oxide levels and migration of breast cancer cells.”


The research was supervised by Professor Abhay Pandit, CRAM’s Chief Scientific Officer, and published in collaboration with Dr Sharon Glynn from the Lambe Institute for Translational Research and Dr Pau Farras from the School of Biological Sciences and Chemistry from the Ryan Institute at the National University of Ireland Galway.

The work investigated the ability of HA to remove nitric oxide. The team found that the conversion of nitric oxide to certain nitrogen-concentrating free radicals causes HA to break down, which further inhibits the migration of nitric oxide by cancer cells in the mass medium. u.

Collectively, these results help to understand the involvement of HA in nitric oxide-induced cell migration and suggest the possibility of using modified HA, as an important material in other biomedical applications. together.

Commenting on the study, Professor Abhay Pandit, said: “While recent advances in research into the role of nitric oxide in tumor progression have ultimately led to a number of clinical trials, ongoing to evaluate the effects of NO-synthase inhibitors, we are focusing on NOT ourselves trying to avoid the side effects/reactions of these inhibitors.”

Source: Newswise

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