The thoracic aorta grows as we age, but changes in vessel size and structure, a phenomenon known as vascular remodeling, are systemic in nature related to hemodynamics-mechanical measures. on cardiovascular function and blood circulation – and the biological processes also implicated in cardiovascular disease.
Study senior author Maryam Kavousi MD, Ph.D., said: “Although thoracic aortic enlargement is a frequent finding in clinical practice, there are few longitudinal data on long-term prognosis. its duration for major population-level cardiovascular disease outcomes. Department of Epidemiology at Erasmus MC, University Medical Center Rotterdam in Rotterdam, Netherlands.
Dr Kavousi and colleagues evaluated these associations in 2,178 participants from the population-based Rotterdam Study. Participants underwent multi-probe CT scans between 2003 and 2006 and were followed for an average of 9 years. Thoracic aortic diameter was indexed for body mass index (BMI).
“Our results suggest that imaging-based assessment of thoracic aortic diameter can be considered a risk marker for future cardiovascular disease,” said Dr. Kavousi.
In women, larger aortic diameter was associated with a 33% higher risk of cardiovascular death. Regeneration of aging aorta appears to vary between women and men with a more rapid deterioration in women.
“Aging may affect aortic health and structure more adversely in women than in men,” says Dr. Kavousi.
Study results suggest that assessing cardiovascular risk related to thoracic aortic size in asymptomatic women and men may lead to effective, sex-specific prevention strategies. .
“Since aortic diameter is significantly related to body size, using indexed aortic diameter to measure body mass may improve its prognostic value for outcomes. cardiovascular,” said Dr. Kavousi. Evaluation of thoracic aortic size could easily be added to existing screening methods, the researchers say. The cardiac CT scan deployed in the study was commonly used to evaluate coronary calcium. Thoracic aortic diameter may also be routinely measured, for example, as part of CT-based lung cancer screening. The present study is based on a single CT-based assessment of the thoracic aorta in a large cohort of participants from the general population, followed for 9 years for cardiovascular outcomes and mortality. . The researchers recently repeated the CT-based assessment of the thoracic aorta among these participants after a median of 14 years. “This presents an exciting and unique opportunity to study the sex-specific risk profiles and developmental patterns of the thoracic aorta in the general population,” said Dr.