Health

Iron supplements can cause a severe allergic attack


Intravenous iron products are commonly used for patients with iron deficiency anemia who cannot digest or are intolerant of oral iron medications. Researchers found the risk of anaphylaxis was

compared with the experience of those using ferrous gluconate, ferric sucrose and ferric carboxymaltose.

Allergic reactions occur more often in the elderly. And those treating them aren’t sure why iron-fortified formulations sometimes unexpectedly cause severe anaphylaxis requiring emergency treatment and even hospitalization.

“It is very important to quantify the risk of anaphylaxis from current intravenous iron formulations because so much remains unknown.” Lead author Chintan Dave, an assistant professor at the Rutgers Center for Pharmacology and Therapeutic Science. “That prompted us to compare specific risks between the five most frequently used products. Our investigation represents an important step forward in understanding this issue.”

He noted that the risk of anaphylaxis across all five IV iron formulations remained very low, but the data showed the highest incidence rates observed for iron dextran, with 10 patients per 10,000 having a reaction. severe allergies, and ferumoxytol, with 4 patients recovering. out of 10,000 people experience anaphylaxis, according to the study.

“We conclude by stating that the rate of anaphylaxis is very low with all intravenous iron products, but three to eight times higher for iron dextran and ferumoxytol than for iron sucrose,” Dave, also a professor at Rutgers Ernest Mario School of Pharmacy, said.

For the study, the researchers used state-of-the-art statistical methods and pharmacological techniques, specifically designed to study drug safety and effectiveness using a critical database. large close.

They reviewed the medical records of about 167,000 older patients collected by Medicare between 2013 and 2018, looking for episodes of anaphylaxis related to the administration of intravenous iron formulations.

“Anaphylaxis is just one of many factors to consider when deciding which IV iron formulation to use” Dave said. “These factors include not only the risk of anaphylaxis but also other factors such as clinical indications, number of IV iron infusions needed, risk of other adverse reactions, and cost.”

Work also provides good news.

“Our findings also provide reassuring data on the risk of anaphylaxis with ferric carboxymaltose, which has seen a rapid increase in use following favorable clinical trial data in a variety of clinical indications ” Co-lead author is Soko Setoguchi, professor of medicine and epidemiology at Rutgers Robert Wood Johnson School of Medicine and Rutgers School of Public Health. “By clarifying the risk of this rare but serious adverse reaction, this information can be used to contribute to the selection of intravenous iron preparations.”


Source: Eurekalert



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