Long-term antibiotic use in cognitive problems Life causes

Many previous studies have highlighted a link between the gut microbiome and the brain, but it’s not clear exactly what the relationship might be. This new study adds more data points in a much-needed research area.

In a cohort of more than 14,000 women, we observed that midlife antibiotic use was significantly associated with poorer scores on global cognition, working and learning memory, as well as speed and psychological attention.“the researchers wrote in their paper.

To our knowledge, our study represents the first large study of chronic long-term antibiotic use and subsequent cognition.“For women taking antibiotics, the resulting brain decline in various areas of learning, response and memory equates to about three or four years of normal aging, according to the data.

This relationship was associated with longer duration of antibiotic use and persisted after adjustment for multiple potential confounders.“the researchers wrote.

The limitation of this study is that it did not consider any specific antibiotics and that it relied on self-reports of antibiotic use. However, the large sample size and the inclusion of other variables, including diet and other medications, increase its value.

Investigations into the link between antibiotics, the gut microbiome, and brain function will continue, but to date, this is one of the best studies we’ve looked at on the effects. Potential long-term effects in adults.

Given the profound effect of antibiotic use on the gut microbiota – with previous studies showing changes in functional potential at two and four years after antibiotic exposure – the axis The gut-brain may be a possible mechanism to link antibiotics with cognitive function“the researchers wrote.

The study was published in PLOS One.

In summary, we find that chronic antibiotic use during midlife is associated with a slight decrease in median assessed cognitive scores seven years later.“, the authors wrote.

These data help to better understand the potential complications of antibiotics throughout life, as well as hypothesize the role of gut microbiota in cognition.. “

Source: Medindia

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