Health

Longest COVID-19 infection lasted for 505 days in UK patient


The researchers studied the virus from nine COVID-19 patients in London, also providing evidence that

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The team, from King’s College London and Guy’s and St Thomas’ NHS Foundation Trust, were also interested in how COVID-19 infection changes over time in immunocompromised people.

Some of these variants are more easily transmitted between people, causing more severe diseases or making vaccines less effective. One theory is that these viral variants develop in people with weakened immune systems due to illness or medical treatments such as chemotherapy, who may have persistent COVID-19 infections.

The study involved nine immunocompromised patients who had tested positive for the virus for at least eight weeks. Infection lasted an average of 73 days, but in two patients the infection persisted for more than a year.

The patients studied between March 2020 and December 2021 had weakened immune systems due to organ transplants, HIV infection, cancer, or medical therapies for other illnesses.

Routine sampling and genetic analysis of the virus revealed that 5 out of 9 patients developed at least one mutation seen in the variants of concern. Some individuals have developed multiple mutations associated with variants of concern, such as the Alpha, Delta, and Omicron variants.

The COVID-19 virus from an individual containing 10 mutations will give rise to distinct variants of concern, such as Alpha, Gamma, and Omicron variants.

This provides evidence that Mutations found in variants of interest arise in immunocompromised patients and thus support the idea that new variants of the virus can develop in immunocompromised individuals..

Five of the nine patients survived. Two of those five have recovered from SARS-CoV-2 infection without treatment, two have recovered after treatment with antibody and antiretroviral therapies, and one individual is suffering from the infection. .

At the last follow-up visit in early 2022, the patient with persistent infection had been infected for more than a year (412 days). At the last follow-up visit in early 2022, the patient with persistent infection had been infected for more than a year (412 days).

The person was treated with monoclonal antibodies to try to clear their infection. If the person remains positive at their next follow-up appointment, they will likely outgrow the 505-day longest known infection described in this report.

Source: Medindia



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