Metabolic key to future kidney disease treatment
“We found that there is a rapid conversion of the amino acid lysine in humans and animals with kidney disease. Rinschen,” explains Markus.
It is estimated that up to 10% of the adult population has chronic kidney disease, although it is often mild and asymptomatic. The most common cause of kidney disease and kidney failure is diabetes or high blood pressure, and as a result a much higher risk of heart attack or stroke.
However, Markus Rinschen assesses that he will not be able to start treating patients in the clinic for at least another 5 years, and he stresses that it is too early for people with kidney disease to be able to buy lysine tablets.
“We don’t know the underlying effects or mechanisms yet, and human metabolism is much more complex than that of mice,” he said.
“We need to do more research in animal models, because we still don’t know the dominant mechanism behind the results. We found three different mechanisms, but we don’t know whether one, two, or a combination of all three, is the determining factor.”
In the long term, the results will be particularly interesting to health researchers, physicians, nephrologists, physiologists, endocrinologists and nutritionists.
“It would be great if kidney patients could achieve results by changing their diet,” says Markus Rinschen.
“We wanted to understand kidney metabolism and this is a big step forward. Giving patients a substance they already have in their bodies and producing clinical outcomes would be a big deal,” the researcher said. new and surprising discovery”, who hopes that the research can lead to a more general understanding of beneficial metabolites.
“Research shows how our metabolism remains dynamic and unexplored, and we need holistic approaches to understand it. Diet, metabolism, heart and the cardiovascular system – many things contribute to the development of kidney disease.”