Led by researchers at NYU Langone Health and its Laura and Isaac Perlmutter Cancer Center, the new study found that people with the highest combined polygenic and environmental risk scores, or highest, are four times more likely to develop colorectal cancer than men and women. scored in the bottom third place.
“Our results help address the rising rates of colorectal cancer among young adults in the United States and other developed countries, and demonstrate the identification of those at high risk for the disease. most feasible,” said Richard Hayes, the study’s senior co-investigator. PhD, DDS, MPH.
Published in Journal of the National Cancer Institute online, the study involved comparing 3,486 adults under age 50 with bowel cancer between 1990 and 2010 with 3,890 similar young men and women without the disease. All were participants in a study that followed people with cancer in North America, Europe, Israel and Australia.
Hayes, a professor in the Departments of Population Health and Environmental Medicine at NYU’s Grossman School of Medicine, cautions that his team’s tool is not yet ready for clinical use. Before it can be widely adopted, he says further testing is needed in larger trials to refine the model, describe how best doctors can use it and demonstrate that, When used, the scoring system can in fact prevent morbidity and mortality.
It remains unclear why the number of colorectal cancers is increasing in young people, says Hayes. In contrast, the number of cases in older adults has decreased significantly due to advances in screening and increased removal of suspected growths before they turn to cancer.
However, he noted, colorectal cancer kills more than 53,000 people each year in the United States. And it is for this reason that the American Cancer Society and federal guidelines now recommend beginning routine screening at age 45.
“Our ultimate goal is to have a predictive test for everyone to gauge when they, based on genetic factors and their personal health, need to start looking at it,” says Hayes. Routine colorectal cancer screening. Ideally, doctors need a tool that can be used long before early warning signs appear, such as abdominal pain, low blood counts, and rectal bleeding.
The latest investigation analyzed data collected from 13 cancer studies in the United States, Canada, United Kingdom, Germany, Spain, Israel and Australia.
Currently, more than 150,000 Americans are diagnosed with colon and rectal cancer each year.
Funding support for the scoring study was provided by National Institutes of Health grants R03CA21577502, U01CA164930, R01CA201407, P30CA016087, P30CA015704, P20CA252728 and T32HS026120.