Health

New strategy to reduce fatigue after COVID-19 vaccine


Post-vaccination adverse effects can affect people’s willingness to receive vaccination or booster doses, hindering efforts to reduce the spread and severity of COVID-19. However, the molecular basis of adverse events following vaccination remains unclear.

To advance their understanding, Syenina and her colleagues analyzed blood samples from 175 healthcare workers who received the BNT162b2 vaccine, Pfizer-BioNTech COVID-19. Specifically, they used blood samples to analyze snapshots of each participant’s gene expression, or which genes were turned on or off.

This analysis shows that people with moderate fatigue after vaccination are more likely to have higher basal expression of genes involved in T-cell activity and natural killer cells – two types of cells. important in the human immune system.

The researchers also tested two different vaccination strategies in mice. Some mice received BNT162b2 through intramuscular injection, the method currently used in human patients, in which the vaccine is injected into the muscle. Other mice received subcutaneous injections, where the vaccine was injected into the tissue just under the skin.

After vaccination, compared with mice vaccinated intramuscularly, mice vaccinated subcutaneously showed immune system responses consistent with the potential for adverse events such as fatigue. lower. However, subcutaneous administration does not appear to affect the protective effect of vaccination.

Further research will be needed to build on these findings and explore their clinical implications. However, they increase understanding of post-vaccination fatigue and offer a potential strategy to reduce its likelihood.

Coauthor Eng Eong Ooi adds, “This study provides the first insight into the molecular basis of a side effect that many people have experienced after mRNA vaccination. We hope that this finding. will spur more research to fully understand the underlying mechanisms behind vaccine-related adverse events and contribute collectively to the development of vaccines that are even more tolerable.”

Source: Medindia



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