Obese adults can benefit from weight loss

It is the third most common cancer and the third leading cause of cancer death in men and women in the United States.

Over the past 30 years, obesity has increased in the United States and around the world, leading to an increase in the development of many chronic diseases.

Fat is a known risk factor for colorectal adenomas and colorectal cancer.

Doctors recommend weight loss for overweight and obese people. Although weight loss is believed to have some beneficial health effects, whether losing weight can reduce the risk of developing colorectal adenomas remains an open question.

Most studies only investigated the risk of colorectal adenomas in relation to obesity or assessed body mass index at one time point, with few examining the role of weight change.

Research details

The researchers here evaluated weight change (including weight gain and weight loss) over three stages of adulthood associated with colorectal adenomas using self-reported weight data in the study. Prostate, lung, colorectal and ovarian cancer screening trial.

The trial involved 154,942 men and women in the United States between the ages of 55 and 74 between 1993 and 2001 to evaluate the effectiveness of different screening methods in preventing death from cancer. different mail. This current study used data from participants in the trial’s screening group, who received the colorectal cancer screening test at baseline and again 3 or 5 years later.

Results of the study

The researchers found that, compared with a steady weight, adult weight loss (defined as losing more than or equal to 1.1 pounds every 5 years) was associated with a 46 percent reduction in risk have colorectal adenoma. This is especially true in adults who were initially overweight or obese.

The investigators also reported that weight gain in adulthood was associated with an increased likelihood of adenomas, particularly weight gain of more than 6.6 pounds over 5 years. The results for weight loss and weight gain appear to be stronger in men than in women.


The researchers believe that these findings demonstrate the importance of maintaining a healthy weight throughout adulthood in preventing colorectal adenomas. Additionally, overweight or obese adults can reduce their risk of developing colorectal adenomas by losing weight.

The study’s senior author, Kathryn Hughes Barry, said: “Our findings suggest that avoiding weight gain in adulthood may help reduce the risk of developing a pre-cancer called colorectal adenoma. colon, which in turn may reduce the risk of developing colorectal cancer. “Based on our findings, we would not recommend weight loss for all adults. But the results suggest that overweight and obese adults may benefit from weight loss.”

Source: Eurekalert

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