OneSkin’s $120 Moisturizer Reverses Your Skin’s Biological Age

Marcela Alcala

I’ll admit that I’m a bit obsessed with the way people around the world are revolutionizing aging. From supplements that change and lengthen our DNA to fasting to the way the food habits of centenarians allow them to surpass 100 years of age, there’s no shortage of exploration when it comes to our quest for longer, healthier lives. In skincare trends, we’re witnessing a similar dedication to maintaining youth. With innovative formulations harnessing cutting-edge ingredients and advanced treatments that target cellular health, the demand for skincare formulas tailored to mature skin is more present than ever. That said, one women-founded brand out of San Francisco is utilizing a science-first approach that has me especially intrigued. Enter OneSkin.

Four PhD-holding scientists whose expertise lie in longevity joined forces in 2021 to create a topical supplement for the face and body that prevents cellular damage in the skin while simultaneously thickening the epidermis. With the brand’s proprietary peptide, the specialized formulas have demonstrated an increased “healthspan” of the skin by addressing the root causes of skin aging, including cellular damage and the accumulation of aged cells. For instance, OneSkin’s Topical Moisturizer ($120) deactivates senescent cells associated with aging, allowing the skin to behave more youthfully, boosting collagen and hyaluronic acid production, and activating cellular-repair pathways in the dermis.

I spoke to the founders of the company about why OneSkin works, the future of skin health, and what’s next for the brand. Keep reading to learn more.

How was OneSkin founded?

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