The study was published in the journal Journal of Bone and Mineral Research.
In a study of 5,212 community-living women aged 75 and older, NSAID use did not appear to have a direct impact on an individual’s risk of fracture, but the drugs appeared to negate the protective effect. Osteoporosis of the oral bisphosphonate, clodronate, to prevent osteoporosis-related fractures.
“We should be cautious when extrapolating these data to bisphosphonates that are more widely used in osteoporosis, but because concomitant use of NSAIDs and bisphosphonates is relatively common, this may cause adverse effects. The clinical consequences were large and resulted in not reducing fracture risk as much as we had hoped,” said senior author Eugene McCloskey, MD, Northern General Hospital, in the UK.