Pea compounds show promise in the treatment of Parkinson’s disease

“We investigated the neuroprotective effects of S. flavescens in Parkinson’s disease based on neuroinflammation,” says Sun. “Our extensive studies indicate that kurarinone has several pharmacological effects, including anti-inflammatory and antioxidant activities.”

The researchers hope this work could lead to an effective therapy for Parkinson’s disease, an incurable, progressive neurodegenerative disorder that affects more than 10 million people worldwide, in That’s one million people in the United States, according to the Mayo Clinic. Most patients are men 65 years of age or older.

“Basically, kurarinone targets soluble epoxide hydrolase (sEH), which is an important regulatory enzyme involved in fatty acid and metabolite metabolism,” said Hammock, a corresponding author on the paper. inhibiting the enzyme sEH addresses neuroinflammation,” said Hammock, a corresponding author on the paper. “The enzyme regulates a newly studied class of natural chemical mediators that in turn regulate inflammation, blood pressure and pain.

Novel mechanism of action

“We’ve known for many years that soluble epoxide hydrolase inhibitors, which are currently being tested safely in humans, reduce the development of Parkinson’s disease in some rodents,” Hammock said. ,” Hammock said. “The evidence for this is quite strong, especially based on the work of our longtime collaborator Kenji Hashimoto at the University of Chiba, Japan.”

Because of regulatory differences, a natural product provides a potentially faster route of pain relief to patients than a classic pharmaceutical drug, Hammock said.

Kurarinone has a novel mechanism compared with other sEH inhibitors, binding to the enzyme at an adjacent but dissimilar site. This provides a new model for designing compounds that are still more active to suppress the neuroinflammation associated with diseases for which sEH inhibitors have been shown to be effective in rodent models including: including Alzheimer’s disease, autism and other disorders, Hammock said.

The study used a Parkinson’s disease model in rats treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Parkinson’s-like behaviors were significantly ameliorated in kurarinone-treated rats. When tested in gene-edited mice with their sEH gene removed, kurarinone provided no additional protection.

Sophora (Arabic name for butterfly pea) is a genus of about 45 species of evergreen trees and shrubs in the legume family, Fabaceae. These species are native to southern Asia, Australasia, various islands of the Pacific Ocean, western South America, the western United States, Florida and Puerto Rico. About 15 of these species have a long history of use in traditional Chinese medicines.

The other authors on the paper are: Christophe Morriseau, UC Davis; Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang and Xiao-Chi Ma, Dalian Medical University.

Source: Eurekalert

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