PRRT Clinical Score Guidelines for Neuroendocrine Tumors

Satya Das, MD, MSCI, an assistant professor of medicine in medicine invented the clinical scoring system, which assigns scores according to organ involvement, type of prior treatment, symptoms, and other factors.

Data from a four-year study, published in Open JAMA Networkindicated that the scoring system could be a clinical tool for patients being considered for PRRT.

PRRT is a radiation and molecular therapy in which a cell-targeting protein is combined with a small amount of radioactive material to create a radioactive substance. When injected into the patient’s bloodstream, the radioactive substance binds to neuroendocrine tumor cells and delivers radiation directly to the cancer cells.

Clinical scores divided patients into groups greater than 4 points and less than or equal to 4 points.

The researchers found that among patients who received three to four doses of PRRT, those with a score of 4 or less experienced a median progression-free survival (NR) compared with 16.92 months. In patients with a score above an impressive 4, this same trend was observed for overall survival.

Patients who received partial doses of one to two treatments had worse outcomes than patients who received the full dose regimen or no PRRT at all. The researchers hypothesized that a minimum of three doses would be required to achieve a meaningful threshold of DNA damage in neuroendocrine tumors in order to suppress tumor growth.

The clinical score was the first validated clinical metric that could predict the predicted benefit from PRRT for a given patient. We are using it in the oncology clinic to guide patients as they prepare to start therapy, said Das, the corresponding study author.

The findings suggest that treatment outcomes may be optimized when patients are less pretreated with other therapies and have a lower degree of metastasis. However, other results from ongoing clinical trials are needed to confirm this suggestion.

The optimal sequence of PRRT remains a major unknown in neuroendocrine tumours.

Our clinical score points towards the benefit of earlier PRRT administration with lutetium dotatate, consistent with preclinical data showing optimized drug DNA damage with lower disease volume. , Das said.

Source: Medindia

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