Health

The COVID-19 virus is attacking the immune system


In the new study, which includes two studies led by an international team, shows how the virus can distinctly evolve in different cell types and adapt to its immunity, in the same organism. infected host.

The team sought to investigate the function of a tailored vesicle in the SARS-CoV-2 mutant protein in the viral infection cycle. The pouch, discovered by the Bristol team in an earlier breakthrough, plays an essential role in virus transmission.

“A constant stream of variants has completely replaced the original virus, with Omicron and Omicron 2 dominating the world,” said Professor Imre Berger, Professor Imre Berger.

They analyzed a variant originally discovered in Bristol, BrisDelta. It has changed shape from the original virus, but the bag we discovered is still there, unchanged.

Interestingly, BrisDelta presents as a small population in patient samples but seems to infect certain cell types better than the virus that dominated the first wave of infections.

Research results show that a person can have several different virus variants in one’s body.

Some of these variants may use kidney or spleen cells as their hiding place, while the body is busy defending against the dominant virus. This may make it difficult for infected patients to completely eliminate SARS-CoV-2.

The team then applied advanced synthetic biology techniques, state-of-the-art imaging and cloud computing to decipher the mechanics of the virus in the workplace.

To understand the function of the bag, the scientists engineered synthetic SARS-CoV-2 virions in vitro, which resemble viruses but have the great advantage that they are safe, because they do not replicate in cells. human cells.

Using these artificial virions, they were able to study the exact mechanism of the vesicle in infecting the virus. They demonstrated that upon binding to fatty acids, the spike protein decorating the virions changed their shape.

This conformational switch could be a mechanism to avoid host detection and robust immune response for longer duration and increase total infectivity.

Interestingly, the same feature also provides us with a unique opportunity to defeat the virus, precisely because it is so well preserved with an antiviral molecule specifically designed to block the pocket.

Source: Medindia



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