thus making them promising targets for the treatment of inflammatory bowel disease (IBD). Therefore, the study analyzed the role of ILCs in IBD as they develop into adult cells.
Immune Cells and IBD
IBD is a gastrointestinal disease characterized by chronic inflammation of the intestinal mucosa. It is known to increase the risk of colon cancer. Although the disease mechanism is unknown (adding a burden to limited treatments), genetic, environmental, and immunological factors are known to play an important role.
“The function of ILCs changes during inflammation, and ILCs are therefore a promising therapeutic target for conditions such as inflammatory bowel disease. Understanding how these cells develop from immature cells Tissue adult cells help us understand how they affect tissue function or inflammation in the mucosa, and how they can be manipulated for therapeutic purposes,” Study first author Efthymia Kokkinou, a doctoral student in the Faculty of Medicine, Huddinge at Karolinska Institutet, said.
“These studies are important because choosing the right treatment can effectively reduce both personal suffering and societal costs.” Jenny Mjösberg, associate professor in the same department at Karolinska Institutet and lead author of the study.