The ‘treasure’ of 58 genetic clues to cancer has been identified

Researchers can detect cancer DNA patterns – or markers of mutations – that provide clues as to whether a patient has been exposed to environmental causes of cancer such as smoking. or UV rays, or whether there are internal or cellular malfunctions.

In the study, published in the journal Science, The team was also able to detect 58 new signatures of mutations, suggesting that there are other causes of cancer that we don’t fully understand.

“Whole genome sequencing gives us a big picture of all the mutations that contribute to each person’s cancer. With thousands of mutations per cancer, we have the power unprecedented power to find commonalities and differences among NHS patients and in doing so we discovered 58 new patients First author, Dr Andrea Degasperi, research associate at the University Cambridge, said.

The team also created FitMS, a computer-based tool to help scientists and clinicians identify old and new markers of mutations in cancer patients, to potentially inform management. more effective cancer treatment.

Previously, scientists knew only 51 markers of mutations, including those caused by smoking or UV light.

Identifying new markers will also allow doctors to look at each patient’s tumor and match it to specific treatments and drugs.

However, these patterns could only be detected in cancer patients whose whole genome sequencing was not done routinely, the researchers said.

According to Serena Nik-Zainal, Professor of genomic medicine and bioinformatics at the University, the signatures of mutations are “like a fingerprint at a crime scene”.

“Some mutational markers have clinical or therapeutic significance – they can highlight abnormalities that can be targeted with specific drugs or may indicate ‘heel’,” said Nik-Zainal. Achilles’ foot is latent in individual cancers, says Nik-Zainal.

Meanwhile, in a separate study, researchers at the University of Alberta, Canada have shown that cancer is not a genetic disease or purely genetic as once thought.

Source: IANS

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