To measure the aging of cells, the researchers looked at the cells’ epigenetic clocks. Epigenetics looks at how DNA coils inside each cell. As we age, the way DNA coils change, and severe infections are changing it in a way that accelerates premature aging.
In this study, the researchers studied many groups and types of tissues, and found that TB bacteria induce disturbances in epigenetic regulation, specifically in the regulation of transepidermal regulation. DNA methylation. These changes correlate with aging induced by oxidative stress and are associated with premature cellular senescence. These processes have been conserved in both guinea pigs and humans.
DiNardo, who also works at Texas Children’s Hospital, says this is an important area to look at after any severe infection, including sepsis or even SARS-CoV-2. The severity of the infection may also play a role in the aging of cells.
Dr Cristian Coarfa, associate professor of molecular and cellular biology at Baylor, said: “A multi-omic epigenetic clock test could become part of the standard of care for infectious diseases and further inform about infectious diseases. risk of comorbidities following chronic diseases or environmental exposures”. co-author of the article. Coarfa also works with the Dan L Duncan Comprehensive Cancer Center in Baylor.
The multi-omic approach will integrate epigenomics and other ‘omics’ data, such as proteomics (generated proteins), metabolomics (metabolites present) and microbiomics (microbiological) data.
“Now that we know the mechanism, there are several ways that we can target it to slow and reduce the premature epigenetic aging that is occurring in these cells,” Coarfa said.
Their report appeared in the magazine Aging.
Source: Eurekalert
