“Health care providers involved in obesity management, obesity researchers, individuals with obesity, and the general public should take note of these new findings. Catia Martins , PhD, said: “, Department of Nutritional Sciences, University of Alabama at Birmingham. Martins is the study’s corresponding author.
The existence or lack, and the clinical relevance of metabolic adaptation in response to weight loss, is one of the most controversial issues in the field of obesity.
A review of the literature found that inter-study differences stemmed from inconsistencies regarding the energy balance and/or weight stability of participants when measurements were taken. perform.
The aim of this retrospective analysis was to determine whether metabolic adaptation, at the RMR level, was related to time to achieve weight loss goal after adjustment for dietary adherence at a group of premenopausal women who were overweight or not.
A total of 65 Black and White premenopausal women aged 21 to 41 years who were overweight were enrolled in the study.
Participants were sedentary (no more than once per week exercising regularly), had normal blood sugar levels, a family history of overweight/obesity in at least one person, first-degree relatives, and Do not use drugs that affect body composition or metabolism. All participants were non-smokers and reported regular menstrual cycles.
The participants in the retrospective analysis came from two different studies — ROMEO and JULIET conducted in the Department of Nutritional Sciences at the University of Alabama at Birmingham with the same sequence of events, methods, and both aimed at aims to identify metabolic predictors for weight gain.
In the ROMEO study, all participants achieved weight loss with diet alone while in the JULIET study, study participants were randomly assigned to one of three groups: weight loss. with aerobics training three times a week, weight loss with resistance training three times a week, and weight loss with diet alone (the same diet as in ROMEO).
For the current study, the researchers included all participants from the ROMEO study and participants who were randomized to diet only from the JULIET study.
All participants were provided with an 800 kcal diet until a BMI was greater than or equal to 25 kg/m2. After a four-week weight-stabilization period at baseline and after weight loss, the trial was conducted during the follicular phase of the menstrual cycle of participants in a fasted state during the patient’s period. hospital stay for four days.
The results showed that the participants lost an average of 16% of their weight over an average of 5 months. Average dietary adherence was about 64%.
There was a significant metabolic adaptation after weight loss (mean 46 kcal/day) and this variable was a significant predictor of the time it took to reach the weight loss goal even after adjusting for confounding factor (adjusted R2 = 0.63, p
Dr. David B. Sarwer, Director of the Center for Obesity Research and Education at Temple University College of Public Health, said: “The results of this investigation provide further evidence of ways that physiology counteracts when people are trying to lose weight. in Philadelphia, Pa.
“A multitude of environmental variables and other social determinants of health also make weight loss and weight maintenance difficult for many people. However, it’s important to remember that even a slight reduction is possible. 5% of initial body weight – much smaller than Sarwer, who was not affiliated with the study, said:
Source: Eurekalert
