Western diet may increase risk of autoimmune diseases

Experts consider environmental factors to be the main culprit behind the rise in cases. The results of the study could help find a cure for these rapidly spreading autoimmune conditions.

“Human genetics haven’t changed in the past few decades. So there must be something changing in the outside world in a way that is increasing our predisposition to autoimmune disease.” James Lee from the Francis Crick Institute in London, who was previously based at the University of Cambridge.

Total Effort Required

Several international efforts involving autoimmune studies are underway to rule out the exact cause of these diseases.

“The number of autoimmune cases started to increase about 40 years ago in the West. However, we are seeing some cases appearing in countries that have never had such diseases before. For example, The biggest recent increase in inflammatory bowel disease cases has been in the Middle East and East Asia. Before that they had barely seen the disease,” he said. Lee said.

Dieting like a culprit

Research says that dietary changes are significantly more noticeable in more countries as people adopt more Western diet and fast food (such as chicken nuggets, burgers, and other processed foods).

“Fast food diets lack certain key components, such as fiber, and evidence suggests that this change affects a person’s microbiome?? which we have in our gut and play an important role in controlling various functions of the body.Changes in our microbiome then cause autoimmune diseases, of which more than 100 types. has now been detected” Carola Vinuesa from the Francis Crick Institute in London, who was previously based at the Australian National University.

Tracing genetic susceptibility

While there is little that can be done to prevent the rapid expansion of fast food brands, researchers must dig deep at a fundamental level to rule out the genetic susceptibility of these brands. individual.

Therefore, understanding the genetic patterns and mechanisms of autoimmune diseases (by tracing DNA differences) could help to better address the global problem.

The team used an extremely powerful technique for (large-scale) DNA sequencing. This helped determine more than 250 DNA Variation implicated in inflammatory bowel disease.

Formulate the right treatment

The rapidly increasing burden of autoimmune diseases poses an imperative need for new but effective drugs and treatment strategies.

Analysis of different genetic pathways and their consequences about autoimmune diseases can help develop better and right treatments for the patients?? a major target for autoimmune research.

Source: Medindia

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